TABLE 2.

MICs of β-lactams for B. cepacia complex isolates 07-34, 09-54, 212, and 5007902; E. coli TOP10 harboring recombinant plasmid pBcSau13 expressing the PenB1 β-lactamase; and the E. coli TOP10 reference strain

β-Lactam(s)aMIC (μg/ml)
B. cenocepacia 07-34 (PenB1)B. cenocepacia 09-54 (PenB2)B. cenocepacia 212 (PenB3)B. cenocepacia 5007902 (PenB4)E. coli TOP10(pBcSau13) (PenB1)E. coli TOP10
Amoxicillin5125125125125124
Amoxicillin+ CLA512512512512164
Ticarcillin5125125125125124
Piperacillin4512128482
Piperacillin + TZB4256128442
Cefuroxime1651251232168
Ceftazidime432160.2510.5
Cefotaxime151251240.250.06
Cefepime32646410.1250.06
Cefoxitin51251251251288
Aztreonam4512512160.50.06
Imipenem8161680.50.25
  • a CLA, clavulanic acid at a fixed concentration of 4 mg/ml; TZB, tazobactam at a fixed concentration of 4 mg/ml.