TABLE 2.

Parameter values for inhibitory sigmoid Emax effect modelsa

PAO1 phenotypeEmax (log10 CFU/ml)E50 (time > MIC)HEcon (log10 CFU/ml)
WT6.060.5512.719.65
Stably derepressed5.060.2011.09.77
ΔoprD4.500.1261.010.38
  • a E max, maximal log kill achievable by the regimen; E50, fractional time > MIC resulting in 50% of the maximal cell kill; H, Hill's constant; Econ, colony counts (log10 CFU/ml) at 24 h in the untreated control group; WT, wild type.