TABLE 2.

Logarithmic and fold changes of time-kill experiments at 24 h in various drug combinations with 1/4 MICa

IsolatePB-D-RIPB-DPB-RID-RI
LogΔ (CFU/ml)Fold changeLogΔ (CFU/ml)Fold changeLogΔ (CFU/ml)Fold changeLogΔ (CFU/ml)Fold change
K. pneumoniae 1≤−3.70b≥5,000≤−3.70b≥5,000≤−3.70b≥5,000≤−3.70b≥5,000
K. pneumoniae 2−2.70500−2.10125+3.5435,000≤−3.70b≥5,000
K. pneumoniae 3≤−3.70b≥5,000−0.847−0.654.4+1.5132
K. pneumoniae 4≤−3.70b≥5,000+3.796,100+4.3020,000+4.3020,000
K. pneumoniae 5≤−3.70b≥5,000−2.70500+3.452,793+3.071,188
A. baumannii 6≤−3.70b≥5,000+0.191.5≤−3.70b≥5,000≤−3.70b≥5,000
A. baumannii 7−2.0100+5.3200,000+0.877.4+5.30200,000
A. baumannii 8−1.6746+0.563.7+2.43267≤−3.70b≥5,000
A. baumannii 9≤−3.70b≥5,000≤−3.70b≥5,000≤−3.70b≥5,000+0.86.3
A. baumannii 10≤−3.70b≥5,000+5.05112,000+5.30200,000+4.010,000
P. aeruginosa 11≤−3.70b≥5,000+1.5636.5+2.95886+0.523.3
P. aeruginosa 12≤−3.70b≥5,000+4.6039,900≤−3.70b≥5,000+4.1714,700
P. aeruginosa 13≤−3.70b≥5,000≤−3.70b≥5,000+4.3020,000≤−3.70b≥5,000
P. aeruginosa 14≤−3.70b≥5,000+5.30200,000+4.3020,000+2.66460
P. aeruginosa 15≤−3.70b≥5,000+4.7556,000+4.3020,000+3.938,600
E. coli 16≤−3.70b≥5,000≤−3.70b≥5,000−1.8163.8+4.3221,100
E. coli 17≤−3.70b≥5,000≤−3.70b≥5,000≤−3.70b≥5,000+5.30200,000
E. coli 18≤−3.70b≥5,000≤−3.70b≥5,000+2.21161+5.03106,000
E. coli 19≤−3.70b≥5,000≤−3.70b≥5,000≤−3.70b≥5,000≤−3.70b≥5,000
E. coli 20≤−3.70b≥5,000+0.372.4+1.7253+3.563,633
  • a PB, polymyxin B; D, doripenem; RI, rifampin.

  • b Maximum log reduction in CFU/ml detectable by assay = (standard inoculum) 5.7 log10 − (lower limit of detection) 2.0 log10.