TABLE 6.

Recovery of single-step resistant mutants

StrainMIC (mg/liter)InoculumHighest BAL30072 concn (mg/liter) at which colonies appearedIncidence of colonies appearing at >4× MIC
BAL30072Meropenem
A. baumannii HPA7451014.4 × 1064None recoveredParent resistant
A. junii 152180.256.6 × 1061None recoveredNone recovered
4.9 × 108
E. cloacae S4741B15.3 × 106167 × 10−7None recovered
E. cloacae S963944.6 × 1068None recoveredNone recovered
2.2 × 108
E. coli W31100.252.7 × 1081None recoveredNone recovered
K. pneumoniae 133866542.4 × 1064None recoveredParent resistant
2.1 × 10816
P. aeruginosa BA12.8 × 1062None recovered10−7
2.5 × 108322.1 × 10−6
P. aeruginosa 52727.1 × 106161.8 × 10−6Parent resistant
7.1 × 108649.6 × 10−8
P. aeruginosa 6210.1254.7 × 10622.5 × 10−610−5
6.7 × 108162.8 × 10−7
P. aeruginosa 86048.5 × 106327 × 10−710−5