TABLE 7.

Development of resistance during serial passage

StrainNo. of passages required for MIC to rise above 4× original MIC
BAL30072MeropenemImipenemCefepimeCiprofloxacin
A. baumannii HPA745106Parent resistant1Parent resistantParent resistant
A. junii 15218209171412
E. cloacae S4741B97354
E. cloacae S963989948
K. pneumoniae 13386659Parent resistant2Parent resistantParent resistant
P. aeruginosa 52793Parent resistant13
P. aeruginosa 62152Parent resistantNot testedNot tested
P. aeruginosa BA53422
S. maltophilia 1AC7364Parent resistantParent resistant1Parent resistant