TABLE 3.

Comparison with previous resultsa

Source of resultst1/2AQ (h)CL/FAQ (liter/h)t1/2αDAQ (h)t1/2βDAQ (h)
Present study7.93,4100.79211
Navaratnam et al. (12)2.3 ± 1.42,504 ± 2,000bNA201 ± 119
Orrell et al. (16)3.9 ± 1.25,160 ± 1,560NA136.9 ± 83.8
Winstanley et al. (25)3.7 ± 1.3NANA60
Winstanley et al. (24)5.2 ± 1.76,060 ± 1,212bNANA
  • a Values are means ± standard errors. t1/2AQ, elimination half-life of amodiaquine; CL/FAQ, apparent clearance of amodiaquine; t1/2αDAQ, distribution half-life of desethylamodiaquine; t1/2βDAQ, terminal half-life of desethylamodiaquine; NA, not applicable.

  • b Values are derived from reported doses and AUCs.