TABLE 3.

Effects of outer membrane protein and efflux pump disruptions on the activity of BAL30072 against P. aeruginosa

StrainDisruptionSource or referenceMIC (μg/ml)
BAL30072MeropenemImipenemCeftazidimeCiprofloxacinPolymyxin B
B4NoneBasilea0.5≤0.061422
C2ΔoprDBasilea0.25132284
PAO1None221210.258
PAO238Δ(mexAB-oprM) Δ(mexCD-oprJ)20.1250.520.5≤0.068
PAO253Overproduces (MexEF-OprN), Δ(mexAB-oprM)80.50.540.2514
PAO267ΔamrRmexZ) Δ(mexAB-oprM)8≤0.060.12510.5≤0.068
PAO750Δ(mexAB-oprM) Δ(mexCD-oprJ) Δ(mexEF-oprN) Δ(mexJK) Δ(mexXY) ΔopmH ΔpscC28≤0.060.520.5≤0.068
860ΔfpvA ΔfpvB ΔfptA ΔpirABasilea11Not testedNot testedNot testedNot tested
(560546)9 M.P.ΔfpvABasilea12Not testedNot testedNot testedNot tested
134ΔpfeABasilea11
BANoneBasilea11120.254
BA(C2-107)Selected with 20 μg/ml BAL30072This study82120.54
BA(C1-106)Selected with 25 μg/ml BAL30072This study1611160.52