TABLE 2.

Activity of BAL30072 against strains with identified β-lactamases as the sole determinant of β-lactam resistance

OrganismEnzyme presentMIC (μg/ml)
BAL30072ATMMEMIPM
E. coli HB101(pAT268)TEM-53232≤0.060.25
E. coli K802N(pAT251)TEM-3>32>321632
E. coli CF102TEM-3432≤0.060.5
K. pneumoniae 1357ETEM-104>32≤0.060.5
E. coli ACTX-M 150.125>320.1250.25
K. pneumoniae 26768WUSHV-5>32>32≤0.061
K. oxytoca 1028EK10.5>320.1250.5
P. aeruginosa 1973EPSE-1, class C4842
P. aeruginosa 1937EPSE-4, class C2412
S. marcescens S6SME-1, AmpC≤0.061632>32
E. coli nmcANMCA1>32>32>32
K. pneumoniae CREKPC-2≤0.06>32>32>32
K. pneumoniae YCKPC-2,TEM-1, SHV-2>32>32>32>32
A. baumannii HPA 74510IMP-40.25323216
P. aeruginosa HPA101-1477IMP-128>32>32
P. aeruginosa HPA10586VIM-1216>32>32
P. aeruginosa HPA996VIM-21832>32
P. rettgeri J96IMP-10.1252>32>32
S. maltophilia B715L1, L20.2532>32>32
E. cloacae 908RAmpC4>320.1251
E. coli “Libyien”CMY-24160.1251
P. aeruginosa BAClass C0.5411
P. aeruginosa 18S/HClass C2>3224
S. marcescens 1T9Class C180.1251
A. baumannii HPA 327009OXA-25416>32>32
A. baumannii HPA 4737OXA-26832>32>32
A. baumannii HPA I-16OXA-270.532>32>32