TABLE 2.

Characteristics of IMP/OXA-58-coproducing Acinetobacter genospecies 3 isolates examined in the present studya

Isolate no.MIC (μg/ml) of antimicrobial agentPresence of gene, genetic element, or gene group (product)Integron cassette gene arrayPulsotype
PIPCROCAZFEPIPMMEMATMSAMTZPSULESBLMBLCHDLbADCISAba1ISAba2ISAba3IS18IS1008repAci1intI
1>64>32>32>163216>1616>644+ (IMP-1)+ (OXA-58)+ (ADC-18)++++ (intI1)blaIMP-1-aac6-II-aadA4, dfrA1-orfCC
2>64>32>32>163216>16≤8>644+ (IMP-8)+ (OXA-58)+ (ADC-43)++++ (intI1)blaIMP-8-aac6-II-aadA4L
4>64>32>32>166464>16≤8642+ (IMP-1)+ (OXA-58)+ (ADC-18)+++++ (intI1)blaIMP-1-aac6-II-aadA4bF
5>64>32>32>161616>16≤8642+ (IMP-1)+ (OXA-58)+ (ADC-43)++++ (intI1)blaIMP-1-aac6-II-aadA4, dfrA1-orfCM
6>64>32>32>161632>1616>644+ (IMP-1)+ (OXA-58)+ (ADC-18)++++ (intI1)blaIMP-1-aac6-II-aadA4, dfrA1-orfCK
7>64>32>32>163216>1616>644+ (IMP-1)+ (OXA-58)+ (ADC-18)++++ (intI1)blaIMP-1-aac6-II-aadA4, dfrA1-orfCL
8>64>32>32>163216>16<8642+ (IMP-1)+ (OXA-58)+ (ADC-18)++++ (intI1)blaIMP-1-aac6-II-aadA4B
10>64>32>32>163232>1616>644+ (IMP-1)+ (OXA-58)+ (ADC-18)++++ (intI1)blaIMP-1-aac6-II-aadA4, dfrA1-orfCI
11>64>32>32>163216>16<8>644+ (IMP-1)+ (OXA-58)+ (ADC-18)++++ (intI1)blaIMP-1-aac6-II-aadA4, dfrA1-orfCI
15>64>32>32>161632>16>16>644+ (IMP-1)+ (OXA-58)+ (ADC-18)++++ (intI1)blaIMP-1-aac6-II-aadA4, dfrA1-orfCJ
1832>32>32>163232>16>16>644+ (IMP-1)+ (OXA-58)+ (ADC-18)+++++ (intI1)blaIMP-1-aac6-II-aadA4, dfrA1-orfCD
  • a Abbreviations: PIP, piperacillin; CRO, ceftriaxone; CAZ, ceftazidime; FEP, cefepime; IPM, imipenem; MEM, meropenem; ATM, aztreonam; SAM, ampicillin-sulbactam; TZP, piperacillin-tazobactam; SUL, sulbactam; ESBL, extended-spectrum β-lactamase; MBL, metallo-β-lacatamase; CHDL, carbapnem-hydrolyzing class D β-lactamase.

  • b The detected CHDL genes, including blaOXA-23-like, blaOXA-24-like, blaOXA-51-like, and blaOXA-58-like.