TABLE 2.

Population PK estimates of the base and the final model

ParameteraBase ModelFinal Model
MeanSEMeanSE
kaAQ (h−1)1.470.571.410.49
CL/FAQ (liter/h)3,6206593,410540
V/FAQ (liters)37,5007,31039,2006,350
θBWV/FNANA1.720.59
FM (%)0.3890.1210.4110.115
k34 (h−1)0.720.250.660.20
k43 (h−1)0.01550.00330.01380.0025
kel (h−1)0.2000.0640.2090.060
θBWkelNANA0.740.27
ω2V/FAQ0.3110.0920.2960.089
ω2kel0.03990.0210.0290.013
σ2AQ0.4760.1640.4440.129
σ2DAQ0.2130.0340.2030.033
  • a kaAQ, absorption rate constant of AQ; CL/FAQ, apparent clearance of AQ; V/FAQ, apparent distribution volume of AQ; θBWV/F, factor of influence of BW on AQ V/F; FM, fraction of AQ metabolized into DAQ; k34 and k43, distribution rate constants of DAQ; kel, elimination rate constant of DAQ; θBWkel, factor of influence of BW on DAQ kel; ω2V/FAQ, interindividual variability of V/FAQ; ω2kel, interindividual variability of kel; σ2AQ, proportional residual error for AQ; σ2DAQ, proportional residual error for DAQ.