Group^{b} | Bacterial tissue burden (log_{10} CFU/g) (mean ± SD) in: | ||
---|---|---|---|

Endocardial vegetations | Spleens | Kidneys | |

No DAP (n = 5) | 7.3 ± 1.0 | 5.4 ± 0.2 | 5.1 ± 0.6 |

DAP-12 (n = 9)^{c} | 6.3 ± 1.8 | 3.2 ± 1.6^{e} | 2.1 ± 1.9^{e} |

DAP-18 (n = 9)^{d} | 4.4 ± 1.6^{e}^{,}^{f} | 2.3 ± 1.6^{e} | 2.5 ± 1.2^{e} |

↵

*a*A daptomycin dose of 12 mg/kg in rabbits produced an AUC of 719 μg · h/ml, comparable to the human 6-mg/kg dose (which produced an AUC of 632 μg · h/ml). A daptomycin dose of 18 mg/kg in rabbits produced an AUC of 965 μg · h/ml, comparable to the human 10-mg/kg dose (which produced an AUC of 1,039 μg · h/ml).↵

*b*The three groups were untreated control rabbits (no daptomycin [No DAP]) and rabbits treated with 12 mg of daptomycin/kg/day for 4 days (DAP-12) or 18 mg of daptomycin/kg/day for 4 days (DAP-18).↵

*c*Eleven rabbits were allocated to this arm. Two rabbits, one found dead on day 1 and the other on day 2, received one dose of daptomycin each and were not included in the data analysis. Two euthanized rabbits were included in the analysis: one, given two doses of daptomycin, was found moribund on day 2 (endocardial vegetation titer of 6.48 log_{10}CFU/g); the other, given three doses of daptomycin, was found moribund on day 4 (vegetation titer of 8.28 log_{10}CFU/g).↵

*d*Nine rabbits were allocated to this arm. One rabbit given two doses of daptomycin was found moribund and euthanized on day 2 (endocardial vegetation titer of 2.79 log_{10}CFU/g) and included in the data analysis.↵

*e*Significantly different from the value obtained for the no-DAP group (*P*< 0.05).↵

*f*Significantly different from the value obtained for the DAP-12 group (*P*< 0.05).