TABLE 1.

Activity of BAL30072 against strains with β-lactam resistance phenotypes

Organism (no. of isolates) and compoundMIC (μg/ml)
50%90%Range
Citrobacter freundii (21)
    BAL300724160.125-32
    Aztreonam>32>32>32
    Imipenem120.5-4
    Meropenem≤0.060.25≤0.06-4
    Cefepime14≤0.06-8
    Ceftazidime>32>32>32
    Piperacillin-tazobactam (8:1)>32>32>32
    Amoxicillin-clavulanic acid (2:1)>32>32>32
    Ticarcillin-clavulanic acid (15:1)>32>32>32
Enterobacter aerogenes (15)
    BAL300720.516≤0.06->32
    Aztreonam4>32≤0.06->32
    Imipenem2160.5-32
    Meropenem0.254≤0.06-16
    Cefepime0.2516≤0.06-16
    Ceftazidime>32>320.125->32
    Piperacillin-tazobactam (8:1)32>324->32
    Amoxicillin-clavulanic acid (2:1)>32>32>32
    Ticarcillin-clavulanic acid (15:1)>32>32>32
Enterobacter cloacae (25)
    BAL300724>32≤0.06->32
    Aztreonam1>32≤0.06->32
    Imipenem240.25-16
    Meropenem≤0.060.25≤0.06-16
    Cefepime0.254≤0.06->32
    Ceftazidime16>320.125->32
    Piperacillin-tazobactam (8:1)16>324->32
    Amoxicillin-clavulanic acid (2:1)>32>32>32
    Ticarcillin-clavulanic acid (15:1)>32>32>32
Escherichia coli (18)
    BAL300721>32≤0.06->32
    Aztreonam>32>320.125->32
    Imipenem0.250.5≤0.06->32
    Meropenem≤0.060.5≤0.06->32
    Cefepime8>32≤0.06->32
    Ceftazidime32>321->32
    Piperacillin-tazobactam (8:1)32>324->32
    Amoxicillin-clavulanic acid (2:1)32>3216->32
    Ticarcillin-clavulanic acid (15:1)32>3232->32
Klebsiella oxytoca (10)
    BAL300720.1254≤0.06-8
    Aztreonam16>32≤0.06->32
    Imipenem0.2510.125->32
    Meropenem≤0.061≤0.06->32
    Cefepime24≤0.06->32
    Ceftazidime18≤0.06->32
    Piperacillin-tazobactam (8:1)>32>322->32
    Amoxicillin-clavulanic acid (2:1)8>324->32
Klebsiella pneumoniae (39)
    BAL3007216>32≤0.06->32
    Imipenem1160.5->32
    Meropenem≤0.0616≤0.06->32
    Cefepime4>32≤0.06->32
    Ceftazidime>32>320.125->32
    Piperacillin-tazobactam (8:1)32>321->32
    Amoxicillin-clavulanic acid (2:1)>32>328->32
    Ticarcillin-clavulanic acid (15:1)>32>328->32
Proteus spp. (21)a
    BAL30072≤0.060.25≤0.06-2
    Imipenem480.5-8
    Meropenem0.1250.5≤0.06-0.5
    Cefepime0.1251≤0.06-32
    Ceftazidime≤0.060.25≤0.06-8
    Piperacillin-tazobactam (8:1)14≤0.06-32
    Amoxicillin-clavulanic acid (2:1)32>328->32
    Ticarcillin-clavulanic acid (15:1)8>321->32
Providencia spp. (20)b
    BAL30072≤0.06≤0.06≤0.06-4
    Imipenem4161->32
    Meropenem0.25>32≤0.06->32
    Cefepime≤0.06>32≤0.06->32
    Ceftazidime1>32≤0.06->32
    Piperacillin-tazobactam (8:1)4320.5->32
    Amoxicillin-clavulanic acid (2:1)>32>32>32
    Ticarcillin-clavulanic acid (15:1)16>320.5->32
Serratia marcescens (12)
    BAL3007224≤0.06->32
    Imipenem280.5->32
    Meropenem0.1254≤0.06->32
    Cefepime120.125-16
    Ceftazidime120.125->32
    Piperacillin-tazobactam (8:1)>32>324->32
    Amoxicillin-clavulanic acid (2:1)>32>32>32
    Ticarcillin-clavulanic acid (15:1)>32>328->32
Acinetobacter spp. (40)
    BAL300720.54≤0.06-32
    Aztreonam>32>328->32
    Imipenem0.2532≤0.06->32
    Meropenem1>32≤0.06->32
    Cefepime32>32≤0.06->32
    Ceftazidime32>320.25->32
    Piperacillin-tazobactam (8:1)1>328->32
    Amoxicillin-clavulanic acid (2:1)>32>328->32
    Ampicillin-sulbactam (2:1)16>322->32
    Polymyxin B432≤0.06->32
Burkholderia spp. (20)
    BAL30072≤0.060.125≤0.06-0.25
    Imipenem32>3216->32
    Meropenem240.25-8
    Cefepime8164-32
    Ceftazidime280.25-8
    Piperacillin-tazobactam (8:1)8322->32
    Amoxicillin-clavulanic acid (2:1)>32>32>32
    Ticarcillin-clavulanic acid (15:1)>32>32>32
Pseudomonas aeruginosa (206)
    BAL30072280.125->32
    Aztreonam16>320.25->32
    Imipenem4>320.5->32
    Meropenem4>32≤0.06->32
    Cefepime16320.5->32
    Ceftazidime16>320.25->32
    Piperacillin-tazobactam (8:1)16>320.5->32
    Amoxicillin-clavulanic acid (2:1)>32>32>32
    Ticarcillin-clavulanic acid (15:1)>32>32>32
    Polymyxin B481->32
Stenotrophomonas maltophilia (105)
    BAL300720.52≤0.06->32
    Imipenem>32>3232->32
    Meropenem8>320.25->32
    Cefepime16>322->32
    Ceftazidime2160.5->32
    Piperacillin-tazobactam (8:1)32>324->32
    Amoxicillin-clavulanic acid (2:1)>32>32>32
    Ticarcillin-clavulanic acid (15:1)2160.25->32
  • a Proteus penneri (n = 1), Proteus mirabilis (n = 10), and Proteus vulgaris (n = 10).

  • b Providencia rettgeri (n = 10) and Providencia stuartii (n = 10).