TABLE 2.

Isolates with >2-fold dilution differences in drug MICs between 24 and 48 h of incubation

Drug and speciesNo. of isolatesMIC (mg/liter) at 24 hMIC (mg/liter) at 48 h
Amphotericin B
    Mucor circinelloides20.0150.125
10.030.5
10.030.25
    Rhizopus oryzae10.061
10.060.5
10.252
Itraconazole
    Cunninghamella spp.20.516
    Mucor circinelloides1216
    Rhizopus oryzae218
1116
10.2516
    Rhizopus microsporus118
Ravuconazole
    Cunninghamella spp.1116
    Rhizopus oryzae10.254
10.54
    Rhizopus microsporus10.58
118
Posaconazole
    Cunninghamella spp.10.2516
    Mucor circinelloides1216
    Rhizomucor variabilis2216
1116
    Rhizopus microsporus118
10.516
Terbinafine
    Mucor circinelloides2232
1216