TABLE 1.

Geometric means and MIC ranges of the antifungal agents tested with the 77 Mucorales isolates

Organism (no. of isolates)Antifungal agentMIC (mg/liter) at 24 hMIC (mg/liter) at 48 h
GMaRangeGMRange
Rhizopus oryzae (26)Amphotericin B0.290.03-3210.125-32
Itraconazole40.125-166.960.25-16
Voriconazole12.134-64168-64
Ravuconazole10.25-161.320.25-16
Posaconazole1.150.06-1620.06-16
Terbinafine24.2516-323216-32
Mucor circinelloides (20)Amphotericin B0.050.015-0.1250.150.06-1
Itraconazole11.891-16161-16
Voriconazole168-64161-64
Ravuconazole11.891-1613.132-32
Posaconazole1.490.25-162.690.25-16
Terbinafine21.532-32321-32
Mycocladus corymbifer (7)Amphotericin B0.080.03-0.250.140.06-0.25
Itraconazole0.680.125-161.350.25-16
Voriconazole14.498-161616
Ravuconazole1.220.5-421-8
Posaconazole0.410.125-160.670.25-16
Terbinafine0.50.25-1610.5-32
Cunninghamella bertholletiae (6)Amphotericin B7.132-327.132-32
Itraconazole3.170.5-810.084-16
Voriconazole168-32168-32
Ravuconazole84-1612.138-16
Posaconazole2.300.5-84.591-16
Terbinafine0.400.03-160.490.03-32
Rhizopus microsporus (6)Amphotericin B0.450.25-10.890.5-1
Itraconazole1.590.5-163.560.5-16
Voriconazole84-168.984-16
Ravuconazole0.890.25-161.780.25-8
Posaconazole0.790.25-83.170.5-16
Terbinafine0.710.125-321.410.25-32
Rhizomucor pusillus (5)Amphotericin B0.050.02-0.1250.100.06-0.125
Itraconazole0.290.125-0.50.440.125-1
Voriconazole5.280.5-166.060.5-16
Ravuconazole0.660.25-20.870.25-2
Posaconazole0.160.06-0.250.280.06-0.5
Terbinafine0.220.125-0.50.330.25-0.5
Rhizomucor variabilis (2)Amphotericin B0.030.02-0.060.090.06-0.125
Itraconazole16161616
Voriconazole16161616
Ravuconazole84-161616
Posaconazole1.411-21616
Terbinafine32323232
Cunninghamella spp. (2)Amphotericin B2.832-444
Itraconazole0.5NAb41-16
Voriconazole16161616-16
Ravuconazole1NA84-16
Posaconazole0.25NA41-16
Terbinafine0.13NA0.180.125-0.25
Actinomucor spp. (2)Amphotericin B111.411-2
Itraconazole20.5-820.5-8
Voriconazole168-3222.6316-32
Ravuconazole0.250.250.50.5
Posaconazole0.060.060.1250.125
Terbinafine0.1250.06-0.250.360.125-1
Apophysomyces spp. (1)Amphotericin B2NA8NA
Itraconazole16NA16NA
Voriconazole16NA16NA
Ravuconazole2NA4NA
Posaconazole0.5NA1NA
Terbinafine2NA2NA
  • a GM, geometric mean.

  • b NA, not applicable.