TABLE 3.

WT and position 237 variant inhibitor kinetics

EnzymeMean Ki (μM) ± SEM
Clavulanic acidSulbactamTazobactam
WT11 ± 1167 ± 1674 ± 7
T237S variant13 ± 197 ± 953 ± 5
T237A variant55 ± 5703 ± 70174 ± 17