TABLE 1.

Patient characteristics

CharacteristicGroup 1Group 2P valuea
No. of patients7063
Age (yr)b58.9 ± 17.860.8 ± 16.10.53
Gender (no. of M/no. of F)c57/1345/180.25d
Body wt (kg)b76.7 ± 17.772.1 ± 11.60.08
Height (cm)b172.7 ± 6.9170.8 ± 7.00.13
BMIe (kg/m2)b25.8 ± 6.324.7 ± 3.50.22
CLCr (ml/min)b,f,g95.9 ± 57.197.1 ± 53.50.90
Vancomycin Cssb,f (mg/liter)15.5 ± 4.815.8 ± 5.00.69
No. (%) of patients with the following reason for hospital admission:
    ICUh ward47 (67.1)31 (49.3)0.09d
    Surgical ward16 (22.9)11 (17.4)0.44d
    Medical ward7 (10.0)21 (33.3)0.01d
Main reason for vancomycin
    Hospital acquired pneumonia22 (31.4)16 (25.4)0.28d
    Empirical use for severe sepsis20 (28.6)23 (36.5)0.21d
    Bloodstream infections13 (18.6)12 (19.1)0.56d
    Cardiosurgical infections10 (14.3)8 (12.7)0.80d
    Intra-abdominal infections5 (7.1)4 (6.3)0.56d
  • a Statistical significance was assessed by means of unpaired t test, unless otherwise specified.

  • b Values are expressed as means ± standard deviations; steady-state concentrations.

  • c M, males; F, females.

  • d χ2 test.

  • e BMI, body mass index.

  • f At time of first TDM.

  • g CLCr was estimated by the formula of Cockcroft and Gault (3).

  • h ICU, intensive care unit.