TABLE 2.

Concentrations and ratios of micafungin in plasma, ELF, and AC

CompartmentDrug concn or ratio between compartments at indicated sampling point (n)
3 h (4)5 h (3a)8 h (4)18 h (4)24 h (4)
Plasma (μg/ml)4.93 ± 0.974.81 ± 0.383.93 ± 0.392.38 ± 0.561.57 ± 0.33
ELF (μg/ml)0.04 ± 0.070.71 ± 0.200.05 ± 0.090.08 ± 0.141.38 ± 1.93
ELF/plasma ratio0.010.150.010.041.10
AC (μg/ml)7.17 ± 13.212.84 ± 1.324.86 ± 5.6217.41 ± 24.259.99 ± 10.68
AC/plasma ratio1.530.611.237.626.22
  • a The subject who received four doses was excluded from the time-group analysis. His plasma, ELF, and AC drug concentrations were 5.38 μg/ml, 0.69 μg/ml, and 53.31 μg/ml, respectively.