TABLE 6.

Polymyxin B MICs of selected P. aeruginosa mutantsa

StrainMIC (μg/ml) (mode)
Without indolicidinWith indolicidin
WT18
parR mutant0.250.125
UW-PA155918
UW-PA17970.5-1b1-2b
UW-pagL18
UW-pmrB0.5-1b2
UW-PA478214
UW-arnB0.250.25
UW-arnC0.250.125
  • a MICs were determined by serial 2-fold dilutions in BM2-glucose minimal medium with 2 mM Mg2+ without indolicidin or with 4 μg/ml indolicidin. The MIC represents the concentration at which no growth was visually observed after 24 h of incubation at 37°C. Results are the mode of 5 or 6 independent experiments.

  • b The MICs varied over the 5 or 6 different experiments.