TABLE 6.

Drug exposures predicted in lung transplant patients receiving micafungin administered intravenously once daily for 14 days

PlasmaACsELF
Day 1
    AUC0-24h (mg.h.L−1)79.2 ± 4.4*208.1 ± 275.614.4 ± 18.4
    AUC ratios**NA2.65 ± 3.510.18 ± 0.23
Day 7
    AUC0-24h (mg.h.L−1)117.4 ± 31.4387.7 ± 437.6137.6 ± 154.1
    AUC ratiosNA3.59 ± 4.081.28 ± 1.41
Day 14
    AUC0-24h (mg.h.L−1)118.1 ± 33.6409.9 ± 467.2214.4 ± 240.2
    AUC ratiosNA3.80 ± 4.361.98 ± 2.16
Day 1 to 14
    AUC0-14d (mg.h.L−1)1584.6 ± 376.95190.6 ± 5958.71864.6 ± 2070.8
    AUC ratiosNA3.53 ± 4.071.27 ± 1.38
  • *All data are given as mean ± SD.

  • **AUC ratio = AC AUC0-24h/Plasma AUC0-24h and ELF AUC0-24h/ Plasma AUC0-24h.