TABLE 4.

Population PK parameter valuesa of the final model

StatisticRandom parametersFixed parameters
CL23CL24CL34V2V3V4CL10K12K21V1
Mean0.2790.009670.3625.4071.60712.0241.3093.0686.79517.617
Median0.09030.01180.01433.5190.85115.361
SD0.7720.02360.7084.9921.4555.712
  • a Subscript numeral correspond to compartments as follows: 1, central (plasma) compartment; 2, peripheral compartment; 3, AC compartment; 4, ELF compartment. K12 and K21 (in h−1) are transfer rate constants between the central and the peripheral compartments. CL10 (in liters/h) is the elimination clearance from the central compartment; CL23, CL24, CL34 (in liters/h) are the intercompartmental clearances. V1, V2, V3, and V4 (in liters) are the volumes of distribution in the indicated compartment.