TABLE 2.

Changes in the AZM MIC and domain V of each 23S rRNA allele following selection by erythromycin

Isolate no. (STa) and stage of selection by erythromycinAZM MIC (mg/liter)23S rRNA domain V allele sequence
Allele 1Allele 2Allele 3Allele 4
136 (ST 1704)
    Preselection0.25WTbWTWTA2059G
    Postselection>256A2059GA2059GA2059GA2059G
352521 (ST 1443)
    Preselection0.25WTWTWTA2059G
    Postselection>256A2059GA2059GA2059GA2059G
252611 (ST 470)
    Preselection0.38WTA2059GWTWT
    Postselection>256A2059GA2059GA2059GA2059G
254921 (ST 649)
    Preselection0.25WTWTWTWT
    Postselection1.5WTWTWTWT
  • a ST, NG-MAST sequence type.

  • b WT, wild type.