TABLE 2.

MIC data for sterol-WT isolates (CA6, CA14, and CA177) and the erg11 erg5 double mutant (CA108) determined using the broth microdilution methoda

IsolateMIC (μg ml−1)b
Standard azole assayPresence of FK506cAmphotericin B assayd
FLUVORIITRAKETOCLOTFLUVORI
CA6 256 16 16 16 1 1.0<0.06250.25
CA141.00.06250.06250.06250.06251.0<0.06250.25
CA177 256 16 16 16 1 0.5<0.06250.25
CA108 64 8 2 1 2 16 4 2
  • a NCCLS document M27-A2 (20).

  • b FLU, fluconazole; VORI, voriconazole; ITRA, itraconazole; KETO, ketoconazole; CLOT, clotrimazole. Values above the suggested clinical breakpoints (27) are in boldface.

  • c 10 μM (27).

  • d Reference 9.