TABLE 3.

Mutations in genes traditionally associated with INH resistancea

ProteinMutation(s) in strain:
507150725297532453585400M. bovisBCG
Rv1484/inhANoneNoneNoneNoneNoneNoneNone
Rv1908c/katGNoneNoneNoneG285VR463LF129SR463L
Rv1909c/furANoneNoneNoneNoneA46VNoneA46V
Rv1854c/ndhNoneNoneNoneNoneG313RNoneG313R
Rv0342/iniANoneNoneNoneNoneN88S, H481QNoneN88S, H481Q
Rv0341/iniBNoneNoneNoneNoneNoneNoneNone
Rv0343/iniCNoneNoneNoneNoneNoneNoneNone
Rv3139/fadE24NoneNoneNoneNoneNoneNoneNone
Rv2245/kasANoneNoneNoneNoneNoneNoneNone
Rv2246/kasBNoneNoneNoneNoneNoneNoneNone
Rv2428/ahpCNoneNoneNoneNoneNoneNoneNone
Rv2242NoneNoneNoneNoneA363TNoneA363T
Rv0340NoneNoneNoneNoneNoneNoneNone
Rv1592cI322VI322VI322VI322VI322VI322VI322V
Rv1772NoneNoneNoneNoneDeletionNoneDeletion
Rv2846c/efpANoneNoneNoneQ513RT15RNoneT15R
Rv0486/mshAN111SN111SNoneN111SNoneN111SNone
  • a Mutations are indicated relative to the amino acid in the H37Rv reference sequence. Synonymous mutations are excluded.