TABLE 1.

Antibiotic susceptibility of P. aeruginosa in the presence or absence of 32 μg/ml of ME1071

Organism (no. of isolates tested) and antibioticME1071aMIC (μg/ml)% Sa% Ra
RangeMIC50MIC90
MBL-producing P. aeruginosa (174)
    Piperacillin0.5->128>128>1283466
+1->128128>1283763
    Ceftazidime2->64>64>64694
+2->6432>643353
    Aztreonam0.25->12832128963
+0.5->12832128864
    Imipenem0.5->64>64>64888
+0.5->6416>641775
    Meropenem0.5->64>64>64686
+0.25->6416>641472
    Biapenem0.12->64>64>64786
+0.12->648>642240
    Doripenem0.25->64>64>64880
+0.25->648>642050
Non-MBL-producing P. aeruginosa (16)
    Piperacillin4->128>128>1281981
+4->128>128>1282575
    Ceftazidime2->6416642550
+2->6416642544
    Aztreonam4->12832>1281356
+4->12832>1281356
    Imipenem1-3216321388
+1-3216321381
    Meropenem0.12-6416642556
+0.25-6416641956
    Biapenem0.5-3216321369
+0.5-3216321363
    Doripenem0.25-328323144
+0.25-328323844
IMP-1-producing P. aeruginosa (166)
    Piperacillin0.5->128>128>1283466
+1->128128>1283763
    Ceftazidime2->64>64>64793
+2->6432>643352
    Aztreonam0.25->12832128764
+0.5->12832128764
    Imipenem0.5->64>64>64887
+0.5->6416>641775
    Meropenem0.5->64>64>64686
+0.25->6416>641372
    Biapenem0.12->64>64>64886
+0.12->648322238
    Doripenem0.25->64>64>64880
+0.25->648>642049
VIM-2-producing P. aeruginosa (8)
    Piperacillin64->128128>1283863
+16->128128>1283863
    Ceftazidime32->6464>640100
+4->6432>643863
    Aztreonam8-128161283850
+8->12832>1283863
    Imipenem16->64>64>640100
+2->6464>641375
    Meropenem16->64>64>640100
+1->6432>642575
    Biapenem8->6464>64075
+0.25->6416>642575
    Doripenem16->6464>640100
+1->6416>642563
  • a Clinical and Laboratory Standards Institute (CLSI) (2010) breakpoints, where available (1), were used. CLSI (2010) does not have criteria (susceptible, intermediate, or resistant) for biapenem or doripenem (1). For comparison only, the same values for imipenem (CLSI, 2010) were used as criteria for biapenem and doripenem. S, susceptible; R, resistant.