TABLE 2.

[3H]TMG accumulation in strain 3-AG100 in the presence of various compounds at concentrations that inhibited Nile Red efflux almost completely (∼90%)

CompoundRadioactivity (cpm)aSDa% Accumulation
None84,70028,800100
TPP (800 μM)82,00020,30097
Doxorubicin (100 μM)65,70014,60078
PAβN (100 μM)50,90014,10060
NMP (800 μM)44,70022,80053
Minocycline (200 μM)38,5005,70045
Doxycycline (800 μM)37,5005,30044
Tetracycline (800 μM)23,1008,70027
Chlortetracycline (200 μM)12,2006,40014
CCCP (200 μM)3,8001,5004.5
  • a At least three independent experiments were performed per inhibitor.