TABLE 5.

Resistance genes and phenotypes of sequenced pSK41-like plasmids

Gene(s)Phenotypic resistancePresencea in the following plasmid:
pSK41 (46.4 kb)pGO1 (54 kb)pLW043 (57.9 kb)pUSA03 (37.1 kb)pV030-8 (39 kb)pTN147 (43.9 kb)pGA672 (47.3 kb)pPAnicu (44.1 kb)
aac6′-aph2Gentamicin, tobramycin, kanamycinXXXXXX
aadDNeomycinXXXXX
qacA, qacB, smrQuaternary ammonium compoundsXXXXX
dfrATrimethoprimXXX
vanAVancomycinX
mupAMupirocinXXXXX
ermCMacrolides-lincosamides-streptograminsX
blaZβ-LactamsX
bleOBleomycinXXX
  • a An X indicates the presence of a gene. The source or reference for each plasmid is given in parentheses as follows: pSK41 (4), pGO1 (5), pLW043 (36), pUSA03 (11), pV030-8 (GenBank accession number NC_010279), pTN147 (this study; GenBank accession number GQ900433.1), pGA672 (this study; GenBank accession number GQ900432.1), and pPAnicu (this study; GenBank accession number GQ900434.1).