TABLE 3.

Pharmacokinetic parametersa

Dose (mg/kg)Cmax (μg/ml)AUC0-∞ (μg·day/ml)t1/2 (days)CL (ml/day/kg)MRT (days)V (liters)
5109 ± 31224 ± 603.13 ± 1.301.97 ± 0.612.76 ± 0.849.17 ± 5.52
10211 ± 57423 ± 1503.33 ± 0.702.36 ± 1.853.15 ± 0.3910.8 ± 6.5
  • a Data represent arithmetic means ± standard deviations.