TABLE 2.

Summary of the association of in vitro QN response (IC50) with polymorphisms in the pfnhe1, pfmdr1, and pfcrt genes from P. falciparum isolates

Genotype and basis of analysisP valueaSignificance
All samplesb60 field isolates
pfnhe1
    ms4760 haplotype0.0100.003S
    His/Asp ratio0.0030.001S
    No. of DNNND repeats0.0010.003S
    No. of DDNHNDNHNND repeats0.0120.001S
pfmdr1
    Codon 860.5730.400NS
    Codon 1840.0670.022NS
    Codon 10340.647NS
    Codon 10420.5190.501NS
    Codon 12460.647NS
pfcrt
    Codons 72 to 760.1980.433NS
    Codon 2200.4070.040NS
  • a P values were determined with the Kruskal-Wallis test. The variables analyzed were the QN IC50s. S, significant; NS, not significant (cutoff of P = 0.0045 [Bonferroni correction]).

  • b All samples included 60 new isolates, 8 laboratory standard strains, and 2 strains established earlier in China.