TABLE 2.

Change in HIV-1 RNA levels

EffectValue (P value) for groupa
Placebo5 mg/kg PRO 14010 mg/kg PRO 140
Maximum log10 change in HIV-1 RNA load−0.32 ± 0.24−1.83 ± 0.23 (<0.0001)−1.83 ± 0.41 (<0.0001)
Day 12 log10 change in HIV-1 RNA load0.02 ± 0.18−1.69 ± 0.36 (<0.0001)−1.73 ± 0.37 (<0.0001)
No. of subjects with a ≥1-log10-unit decrease in HIV-1 RNA level/total no. in group (%)0/11 (0)10/10 (100) (<0.0001)9/9 (100) (<0.0001)
No. of subjects with a ≥2-log10-unit decrease in HIV-1 RNA level/total no. in group (%)0/11 (0)2/10 (20)5/9 (56) (<0.01)
  • a Data are mean ± SD values, unless otherwise indicated. The analysis excludes data for one subject in the 10-mg/kg PRO 140 group who was reclassified as having dual/mixed virus at screening.