TABLE 1.

Intravenous colistin dosing based on renal function

Dose descriptionRecommended dosingb based on baseline creatinine clearance:
>80 ml/min (n = 20)30-80 ml/min (n = 10)
Recommended dosea5 mg/kg/day2.5-3.8 mg/kg/day
Dosing based on:
    Actual body weight4.2 ± 1.23.3 ± 1.1
    Ideal body weight5.3 ± 2.94.7 ± 1.2
Analysis of patient dosec:
    Excessive9.0 ± 3.8 (n = 5)5.0 ± 0.6 (n = 9)
    Normal5.0 ± 0.3 (n = 5)None
    Low-normalc3.6 ± 0.7 (n = 10)1.8 (n = 1)
  • a Dosing recommendations based on those of Evans et al. (3).

  • b All dosing expressed as mean ± standard deviation in mg/kg/day.

  • c Excessive, normal, or low-normal dosing corresponded to a daily dose that was greater than, within, or lower than 0.4 mg/kg/day, respectively, of the recommended dose using ideal body weight. Creatinine clearance as calculated by Cockcroft and Gault (1).