TABLE 1.

Antibiotic susceptibility of the different K. pneumoniae strainsa

StrainPutative overexpressed effluxMembrane protein contentMIC (mg/liter)
PorinsOmpANAL (≤8, >16)CIP (≤0.5, >1)LEV (≤1, >2)CMP (≤8, >8)CTX (≤1, >2)CAZ (≤1, >8)FOX (≤8, >32)ETP (≤0.5, >1)
ATCC 138821++40.030.0320.060.12520.007
KPBj1 E++++320.511280.1250.2580.007
KPBj1 Rev++20.0150.0320.060.12520.007
KPBj1 E+ P−++320.511280.250.125320.5
KPBj1 Rev P−+20.030.0640.250.125320.5
KPBj1 E+ ESBL§+++3210.51281283280.125
KPBj1 Rev ESBL++40.030.0321281620.03
KPBj1 E+ P− ESBL++322112825632324
KPBj1 Rev P− ESBL+40.060.06425632322
KPBj3 E++++320.250.51280.060.2540.007
KPBj3 Rev++20.0150.0340.060.12520.007
KPBj3 E+ P−++320.50.51280.250.25320.25
KPBj3 Rev P−+20.030.01540.250.25320.25
KPBj5 E++++80.060.12580.1250.2580.015
KPBj5 Rev++20.0150.0620.060.12520.007
KPBj5 E+ P−+±+80.1250.12580.250.25320.25
KPBj5 Rev P−+20.030.0620.1250.125160.25
  • a NAL, nalidixic acid; CIP, ciprofloxacin; LEV, levofloxacin; CMP, chloramphenicol; CTX, cefotaxime; CAZ, ceftazidime; FOX, cefoxitin; ETP, ertapenem; §, ESBL, CTX-M-15; +, present; −, absent; ±, very weak. Breakpoints according to the French Antibiogram Committee are given in parentheses following respective antibiotics.