TABLE 2.

Estimated population pharmacokinetic parametersa

ParameterCMSColistin
CL (liters/h)V1 (liters)Q (liters/h)V2 (liters)Residual errorCL/fm (liters/h)V/fm (liters)Residual error
Proportional (%)Additive (nmol/liter)Proportional (%)Additive (nmol/liters)
Typical value (% RSE)13.7 (10)13.5 (45)133 (35)28.9 (22)22.0 (5.4)9.11 (11)9.09 (19)189 (12)7.19 (9.1)4.98 (12)
IIV (% CV)37 (15)59 (36)35b (34)35b (34)
IOV (% CV28 (12)58 (25)43 (16)c43 (16)c
  • a V1, volume of distribution of the central compartment for CMS; V2, volume of distribution of the peripheral compartment for CMS; Q, intercompartmental CL for CMS; CL, clearance of CMS; CL/fm, clearance of formed colistin; V/fm, volume of distribution of formed colistin; RSE, relative standard error.

  • b A common IIV for the residual error terms was used.

  • c For colistin, a common IOV for CL/fm and the volume of distribution of formed colistin was used.