TABLE 4.

Natural polymorphisms within TK and DNA polymerase identified among 94 clinical isolates and 3 laboratory strains of HSV-1 and HSV-2a

VirusTKDNA polymerase
Amino acid changeNo. of isolates (%)ReferenceAmino acid changeNo. of isolates (%)Reference
HSV-1 (n = 44)C6G14 (31.8)31, 47G12E1 (2.3)
A12P1 (2.3)F23I1 (2.3)
R20S1 (2.3)S33G40 (90.9)10, 47
N23S44 (100)31, 47Q42K1 (2.3)
R30C1 (2.3)E70D1 (2.3)
K36E44 (100)31, 47A102T1 (2.3)
K36D1 (2.3)R116H1 (2.3)
R41H1 (2.3)10, 47G132C1 (2.3)
L42P15 (34.1)31, 47P137Q1 (2.3)
R89Q26 (59.1)31, 47A138V1 (2.3)
E111K1 (2.3)A330R44 (100)10, 47
V138I1 (2.3)15I352V1 (2.3)
E146G1 (2.3)E421D1 (2.3)
V191A1 (2.3)N425T5 (11.4)
A192V2 (4.5)37, 47T434M1 (2.3)
G240E11 (25)31, 47A646T3 (6.8)50
A243S1 (2.3)18D660E1 (2.3)
G251C9 (20.5)37, 47D672N3 (6.8)
A265T43 (97.7)31, 47E675A1 (2.3)
V267L8 (18.)231, 47D703N1 (2.3)
P268T12 (27.3)31, 47N711K1 (2.3)
E273Q1 (2.3)G749D1 (2.3)
E273K1 (2.3)L753M1 (2.3)
D286E9 (20.5)31, 47P875S1 (2.3)
H323Y1 (2.3)V905M33 (75)18, 47
A334T1 (2.3)P920S4 (9.1)3, 40
V348I9 (20.5)10, 47A995T1 (2.3)
S357C1 (2.3)E1082K1 (2.3)
N376H4 (9.1)10, 37A1099T1 (2.3)
N376P3 (6.8)10, 31E1104D1 (2.3)
S1113C1 (2.3)
S1123L1 (2.3)
P1124H17 (38.6)10, 47
G1129V1 (2.3)
E1194D1 (2.3)
P1199Q2 (4.5)
A1203T2 (4.5)10, 47
A1204T1 (2.3)
T1208A37 (84.1)10, 47
A1209T1 (2.3)
T1219M1 (2.3)
HSV-2 (n = 54)A27T2 (3.8)10A9T49 (92.5)1, 10
G39E40 (73.6)10P15S49 (92.5)10, 47
N78D19 (34)10P37L1 (1.9)
E96D1 (1.9)R41H8 (15.1)
A135P1 (1.9)Q43R1 (1.9)
D137E1 (1.9)H49Y1 (1.9)
L140F16 (28.3)10L60P49 (92.5)1
A215T2 (3.8)10E139K16 (30.2)10, 47
A232T6 (11.3)47
G324E2 (3.8)
Q507H1 (1.9)
D671N1 (1.9)
D676N1 (1.9)
D676G4 (7.5)
E678G11 (20.8)16, 44
G680R1 (1.9)
E682K1 (1.9)
Q799R1 (1.9)
T801P6 (11.3)10, 47
T903M1 (1.9)
A1000T1 (1.9)
A1083T1 (1.9)
A1114V1 (1.9)
E1149G1 (1.9)
A1223V1 (1.9)
del DGDE (683-686)2 (3.8)
del GD (681-682)1 (1.9)
del DD (676-677)1 (1.9)
del DED (677-679)1 (1.9)
del PGDEPA (1106-1111)1 (1.9)
ins DGDE (683-686)1 (1.9)
  • a del, deletion; ins, insertion. Amino acid changes never previously reported are in bold.