TABLE 2.

MIC data for study isolates

IsolateMIC (μg ml−1)a
Standard azole MIC assayFK506cbAmphotericin B assay (AMB)
FLCVORITCKTCCLTFLC + FK506VOR + FK506
CA625616161611.0<0.06250.25
CA141.00.06250.06250.06250.06251.0<0.06250.25
CA17725616161610.5<0.06250.25
CA12>256>16>16>161>256>160.5
CA488>256>16>16812.00.06250.25
CA490>256>16>16812.00.06250.25
CA1008>256>16>16>161>256>161
  • a Determined using CLSI broth microdilution methodology (23). Values above the suggested clinical breakpoints for C. albicans are in boldface.

  • b MICs in the presence of 10 μM FK506, a drug efflux inhibitor (19).