TABLE 3.

Activities of mechanism-based inhibitors against GES β-lactamase variants

InhibitorIC50 (μM)a
GES-1 (E104, G170)GES-7 (K104, G170)GES-2 (E104, N170)GES-5 (E104, S170)GES-6 (K104, S170)GES-13 (K104, N170)
Clavulanic acid0.10.80.080.51.70.09
Sulbactam1.51.30.54.58.00.3
Tazobactam0.030.060.030.50.50.04
  • a Values are means for three measurements differing by <10%.