TABLE 3.

TK and DNA polymerase comparison, at both nucleotide and amino acid levels, among 94 clinical isolates and 3 laboratory strains of HSV-1 and HSV-2

ParameteraTKDNA polymerase
HSV-1 (n = 44)HSV-2 (n = 53)HSV-1 (n = 44)HSV-2 (n = 53)
Nucleotide identity (%)97.5-99.299.6-10099.4-99.899.7-100
Nucleotide mutations (no.)722515651
Frequency per 100 bp (mean)0.8-2.5 (1.2)0-0.4 (0.2)0.2-0.6 (0.4)0-0.3 (0.1)
Silent mutations (%)61.16873.751
Amino acid identity (%)97.3-98.998.9-10099.4-99.899.3-100
Amino acid changes (no.)3084125
Frequency per 100 aa (mean)1.1-2.7 (1.6)0-1.1 (0.4)0.2-0.6 (0.4)0-0.7 (0.3)
Variation of the total codons (%)82.13.32
  • a aa, amino acids.