TABLE 3.

Antimicrobial resistance profiles of M05/0060 harboring the cfr-encoding conjugative plasmid pSCFS7, its cured derivative M05/0060-C1 lacking pSCFS7, S. aureus recipient strain XU21, and its transconjugant derivative XU21-T1 harboring pSCFS7

Isolate or derivativecfr and fexA carriageMIC (μg/ml)a
TIAVIR M1Q-DLZDCLICHLFFCERYOXAVAN
MRSA M05/0060cfr, fexA≥1283228≥128256256≥64≥321
MRSA M05/0060-C1110.510.2584≥64≥321
S. aureus XU21110.2510.25840.50.121
S. aureus XU21-T1cfr, fexA≥1283224≥1281282560.50.121
  • a TIA, tiamulin; VIR M1, virginamycin M1; Q-D, quinupristin-dalfopristin; LZD, linezolid; CLI, clindamycin; CHL, chloramphenicol; FFC, florfenicol; ERY, erythromycin; OXA, oxacillin; VAN, vancomycin. Resistance to tiamulin, virginamycin M1, quinupristin-dalfopristin, linezolid, clindamycin, chloramphenicol, and florfenicol is indicative of the PhLOPSA phenotype.