TABLE 4.

Impacts of the presence of white blood cells and the site of infection on the static dose and the Cmax and 72-h AUC/MIC required for the static dose of MX-2401 against S. pneumoniae ATCC 10813 in normal and neutropenic mice

ExptInfection siteWhite blood cellsStatic dose (mg/kg)Cmax/MIC72-h AUC/MIC
1ThighNeutropenic9.41431,835
Normal2.865.4968
2ThighNeutropenic4.285.11,199
Normal1.741.3620
LungNeutropenic5.41001,369
Normal3.271.31,039