TABLE 1.

Concentrations of inhibitors required to reduce active enzyme concentration by 50% after a 5-min enzyme-inhibitor preincubation

Enzyme class and nameIC50 (μM)a
CLATZBSULNXL104
Class A
    TEM-10.0580.0321.560.008
    CTX-M-150.0120.0060.230.005
    KPC-2>10050570.170
    SHV-40.0040.0550.260.003
Class C
    P99>1001.321.10.1
    AmpCb>1004.6270.128
  • a Standard deviation of <20% for all IC50s except CTX-M-15, for which the standard deviation was 0.082 μM.

  • b From P. aeruginosa.