TABLE 1.

Characteristics and synergy testing of the epidemic strains

IsolateStrainSusceptibilitiesaSynergy testing result
Lowest FICI2-well synergyTime-kill assaySBPI
ATCC 19606ATCC 19606AMC, TZP, IPM, MEM, CIP, GEN, TOB, CST, MIN, SUL0.56IndifferentBactericidal, inhibition of regrowth12
AB11SE cloneAMK, TOB, CST0.5SynergyBactericidal, inhibition of regrowth8
AB14OXA-23 clone 1CST0.375SynergyBactericidal, inhibition of regrowth6
AB16OXA-23 clone 2AMK, CST0.53IndifferentBactericidal, regrowth at 48 h2.25
AB184“T” strainIPM, MEM, AMK, TOB, CST0.375SynergyBactericidal, inhibition of regrowth8
AB186“Burn” strainAMK, TOB, CST, MIN0.375SynergyBactericidal, inhibition of regrowth2.25
  • a Abbreviations: AMC, amoxicillin-clavulanate; TZP, piperacillin-tazobactam; IPM, imipenem; MEM, meropenem; CIP, ciprofloxacin; GEN, gentamicin; TOB, tobramycin; CST, colistin; MIN, minocycline; SUL, sulbactam; AMK, amikacin.