TABLE 3.

In vitro susceptibilities of the C. gattii strains according to geographical origin

C. gattii strain originDrugMIC (μg/ml)
Range50%Geometric mean90%
Africa (n = 28)Amphotericin B0.125-0.50.250.3200.5
Flucytosine1-1622.3788
Fluconazole0.25-3244.3088
Itraconazole<0.016-0.250.1250.1110.25
Voriconazole<0.016-0.250.1250.1140.25
Posaconazole<0.016-0.250.1250.1220.25
Isavuconazole<0.016-0.50.0630.0580.125
Asia (n = 22)Amphotericin B0.125-0.50.250.3120.5
Flucytosine0.5-16228
Fluconazole0.5-1622.7418
Itraconazole0.031-0.50.1250.10.250
Voriconazole0.031-0.250.0630.080.250
Posaconazole0.063-0.50.1250.1070.250
Isavuconazole0.016-0.250.0310.0440.125
Australia (n = 20)Amphotericin B0.125-0.50.250.2970.5
Flucytosine1-3223.13816
Fluconazole0.5-1622.6398
Itraconazole0.063-0.50.1250.1340.25
Voriconazole0.031-0.250.1250.0910.25
Posaconazole0.031-0.50.1250.1210.25
Isavuconazole0.016-0.1250.0630.0490.125
Europe (n = 101)Amphotericin B<0.016-10.250.2230.5
Flucytosine0.125->6422.2638
Fluconazole0.5-3243.3018
Itraconazole<0.016-0.50.1250.1370.25
Voriconazole<0.016-10.1250.1120.25
Posaconazole<0.016-0.50.1250.1310.25
Isavuconazole<0.016-0.50.0630.0550.125
North America (n = 95)Amphotericin B0.125-0.50.250.3000.5
Flucytosine1-1644.3348
Fluconazole0.5-6444.2408
Itraconazole<0.016-10.1250.1210.25
Voriconazole<0.016-10.1250.1140.25
Posaconazole<0.016-0.50.1250.1030.25
Isavuconazole<0.016-0.50.0630.0470.25
South America (n = 81)Amphotericin B0.125-10.250.2770.5
Flucytosine0.5-1642.8658
Fluconazole0.25-1643.54816
Itraconazole<0.016-10.1250.1260.25
Voriconazole<0.016-0.50.1250.1110.25
Posaconazole<0.016-0.50.1250.1040.25
Isavuconazole<0.016-0.50.0630.0510.25