TABLE 4.

Model building, parameters, and bootstrap runs for PYR disposition

ParameterBase modelFinal covariate modelBootstrap replicates (n = 1,000; median [95% empirical CI])
OFV8,134.5898,088.8228,071.221 [7,830.382-8,312.113]
Pharmacokinetic parameters (estimate [RSE%])
    CL/F (liters/h/70 kg)1.22 [5.2]0.87 [5.2]0.869 [0.788-0.962]
    Pregnancy on CL/F (liters/h/70 kg)0.439 [19.3]0.432 [0.302-0.569]
    VC/F (liters/70 kg)189 [5.5]146 [4.0]145 [135-156]
    Pregnancy on VC/F (liters/70 kg)76 [1.8]76.7 [56-99.8]
    VP/F (L/70 kg)123 [13.2]76.8 [8.7]77.1 [64.8-90.7]
    Pregnancy on VP/F (liters/70 kg)98 [23.9]101 [53.2-1205]
    ka (/h)1.84 [22.8]1.84 [19.4]1.83 [1.32-2.7]
    Q/F (liters/h/70 kg)0.52 [16.3]0.51 [12.9]0.51 [0.4-0.66]
Random parameters (CV% [RSE%])
    BSV CL/F36.5 [9.4]27.6 [8.5]7.3 [4.9-10.1]
    BSV VC/F36.1 [9.8]24.6 [10.7]5.8 [3.6-8.6]
    BSV VP/F65.3 [12.3]42.5 [13.6]16.3 [4-28.6]
    BSV Q/F55.9 [15.8]57.5 [13.7]29.6 [12.1-49.3]
    BSV ka10.6 [14]10.7 [13.3]112 [67-187]
Correlations between BSV pairs
    R (CL/F, VC/F)0.8890.7970.802 [0.672-0.897]
    R (CL/F, VP/F)0.8320.7560.787 [0.458-0.995]
    R (VC/F, VP/F)0.8580.7310.728 [0.427-0.995]
Residual unexplained variability (RUV)
    Proportional error in PYR (μg/liter [RSE%])19.3 [5]19.2 [4.9]19.4 [17.3-21.3]