TABLE 1.

Activity of V-073 against individual polioviruses

StrainCountry/Year collectedSerotypeOriginEC50 ± SDc
10235Dominican Republic/2000PV1cVDPV0.018 ± 0.003
10236Dominican Republic/2000PV1cVDPV0.029 ± 0.021
10238Dominican Republic/2000PV1cVDPV0.014 ± 0.006
10237Haiti/2000PV1cVDPV0.011 ± 0.005
10239Haiti/2001PV1cVDPV0.014 ± 0.003
10240Haiti/2001PV1cVDPV0.015 ± 0.007
10241Haiti/2001PV1cVDPV0.083 ± 0.055
10242Haiti/2001PV1cVDPV0.017 ± 0.013
10690Philippines/2001PV1cVDPV0.029 ± 0.006
10691Philippines/2001PV1cVDPV0.018 ± 0.012
10692Philippines/2001PV1cVDPV0.029 ± 0.015
10693Philippines/2001PV1cVDPV0.008 ± 0.003
10694USA/2005PV1iVDPV0.014 ± 0.002
10695USA/2005PV1iVDPV0.008 ± 0.005
10668Taiwan/2002PV1iVDPV0.021 ± 0.015
10689Taiwan/2002PV1iVDPV0.042 ± 0.029
10223USA/1982PV1iVDPV0.010 ± 0.008
10222USA/1981PV1iVDPV0.015 ± 0.009
10225USA/1990PV1iVDPV0.017 ± 0.010
10224USA/1987PV1iVDPV0.069 ± 0.064
BrunhildeUSA/1939PV1Wild0.018 ± 0.009
MahoneyUSA/1942bPV1Wild0.076 ± 0.052
Sabin 1 OPVaPV1Vaccine0.017 ± 0.000
10229Egypt/1993PV2cVDPV0.020 ± 0.022
10230Egypt/1998PV2cVDPV0.036 ± 0.019
10231Egypt/1998PV2cVDPV0.028 ± 0.013
10232Egypt/1999PV2cVDPV0.019 ± 0.013
10233Egypt/1999PV2cVDPV0.024 ± 0.014
10234Egypt/1999PV2cVDPV0.009 ± 0.001
10219Madagascar/2002PV2cVDPV0.023 ± 0.014
10220Madagascar/2002PV2cVDPV0.010 ± 0.007
10243Nigeria/2002PV2cVDPV0.038 ± 0.008
10221USA/1999PV2iVDPV0.027 ± 0.008
10228USA/1992PV2iVDPV0.126 ± 0.063
10226USA/1991PV2iVDPV0.019 ± 0.001
10227USA/1991PV2iVDPV0.019 ± 0.019
LansingUSA/1937PV2Wild0.007 ± 0.000
MEF-1Egypt/1942bPV2Wild0.026 ± 0.025
P712USA/1954PV2Wild0.003 ± 0.000
Sabin 2 OPVaPV2Vaccine0.016 ± 0.012
10804Egypt/2007PV3iVDPV0.042 ± 0.026
10805Iran/2007PV3iVDPV0.029 ± 0.005
SaukettUSA/1962bPV3Wild0.062 ± 0.008
LeonUSA/1937PV3Wild0.109 ± 0.119
Sabin 3 OPVaPV3Vaccine0.020 ± 0.007
  • a The Sabin type 1, 2, and 3 oral polio vaccine (OPV) strains are PV1-LSc/2ab, PV2-P712, and PV3-Leon, respectively.

  • b PV1-Mahoney, PV2-MEF-1, and PV3-Saukett are seed strains for inactivated polio vaccine.

  • c All values are in μM and based on at least two independent determinations.