TABLE 1.

Summary of baseline demographic characteristics

CharacteristicaValue for:
Ishak group 1Ishak group 2Ishak group 3Total
No. of patients2022951
Age (yr)
    Mean48.747.550.448.5
    Minimum-maximum values32-7034-7640-6532-76
Sex (no. [%] of patients)
    Male18 (90.0)14 (63.6)8 (88.9)40 (78.4)
    Female2 (10.0)8 (36.4)1 (11.1)11 (21.6)
Race (no. [%] of patients)
    White18 (90.0)19 (86.4)8 (88.9)45 (88.2)
    Black2 (10.0)3 (13.6)1 (11.1)6 (11.8)
Mean BMI (kg/m2)25.924.727.425.7
HIV RNA load (log10 copies/ml)
    Median2.052.271.872.03
    Minimum-maximum values1.23-4.31.23-2.831.70-3.801.30-4.30
CD4+ count (no. of cells/mm3)
    Median404.5394.5376.0400.0
    Minimum-maximum values141-835149-161211-602141-861
Baseline viral hepatitis (no. [%] of patients)
    HBsAg negative/HCV Ab negative7 (35.0)4 (18.2)1 (11.1)12 (23.5)
    HBsAg positive/HCV Ab negative3 (15.0)1 (4.5)0 (0.0)4 (7.8)
    HBsAg negative /HCV Ab positive9 (45.0)17 (77.3)8 (88.9)34 (66.7)
    HBsAg positive/HCV Ab positive1 (5.0)0 (0.0)0 (0.0)1 (2.0)
Ishak score (no. [%] of patients)b
    116 (80.0)0 (0.0)0 (0.0)16 (31.4)
    24 (20.0)0 (0.0)0 (0.0)4 (7.8)
    30 (0.0)18 (81.8)0 (0.0)18 (35.3)
    40 (0.0)4 (18.2)0 (0.0)4 (7.8)
    50 (0.0)0 (0.0)6 (66.7)6 (11.8)
    60 (0.0)0 (0.0)3 (33.3)3 (5.9)
Child-Pugh score (no. [%] of patients)
    Noncirrhotic20 (100.0)22 (100.0)0 (0.0)42 (82.4)
    Child-Pugh score A (cirrhotic)0 (0.0)0 (0.0)8 (88.9)8 (15.7)
    Missing (cirrhotic)0 (0.0)0 (0.0)1 (11.1)1 (2.0)
  • a BMI, body mass index; Ab, antibody.

  • b Ishak score 1, fibrous expansion of some portal areas, with or without short fibrous septa; Ishak score 2, fibrous expansion of most portal areas, with or without short fibrous septa; Ishak score 3, fibrous expansion of most portal areas with occasional portal-to-portal bridging; Ishak score 4, fibrous expansion of portal areas with marked portal-to-portal bridging as well as portal-central bridging; Ishak score 5, marked portal-to-portal and/or portal-central bridging with occasional nodules (incomplete cirrhosis); Ishak score 6, cirrhosis probable or definite.