TABLE 3.

Susceptibility of various enterovirus species to V-073a

Virus (no. of viruses tested)EC50 rangeMean EC50MIC90
Poliovirus (45)b0.003-0.1260.0290.076
Echovirus (64)c0.009-7.080.862.12
Coxsackievirus (100)d0.007->14f3.79>14
Enterovirus (9)e0.236->143.471.42
  • a All values are in μM.

  • b Viruses used in Table 1.

  • c Of the 64 viruses tested, 56 were clinical isolates, and 8 were laboratory strains comprising serotypes 3, 4, 5, 6, 7, 9, 11, 24, and 30 (1).

  • d All viruses tested were clinical isolates comprising serotypes A9, B1, B2, B3, B4, and B5 (1).

  • e All viruses tested were clinical isolates comprising serotypes 68, 70, and 71.

  • f The solubility limit in cell culture medium is approximately 14 μM.