TABLE 4.

Geometric mean for overall morning Cmins and Cmins of oxidative metabolites by Ishak group

MetaboliteCmin (ng/ml)
Overall, morningaIshak group 1 (n = 20)bIshak group 2 (n = 22)bIshak group 3 (n = 9)b
2-Hydroxynevirapine186 (47)177 ± 106 (127, 226)226 ± 99 (181, 271)198 ± 75 (141, 256)
3-Hydroxynevirapine646 (47)759 ± 544 (504, 1,013)687 ± 389 (510, 864)849 ± 367 (567, 1,130)
8-Hydroxynevirapinec29 (14)8 ± 15 (−0.3, 16.4)9 ± 15 (1.6, 15.7)24 ± 24 (0.9, 46.2)
12-Hydroxynevirapine483 (48)504 ± 288 (369, 639)650 ± 393 (470, 829)529 ± 178 (393, 666)
4-Carboxynevirapine18 (27)11 ± 12 (5.5, 17.0)15 ± 15 (7.9, 21.4)8 ± 8 (0.7, 14.7)
  • a Values are means (number of samples).

  • b Values are means ± standard deviations (95% confidence intervals).

  • c Nine patients had undetectable plasma 8-hydroxynevirapine concentrations.