TABLE 2.

Telavancin multistep resistance selection results

StrainTime of MICaMIC (μg/ml)b
TelavancinVancomycinTeicoplaninDaptomycinLinezolid
SA525 (VSSA)Initial0.52114
Final (passage no.)1 (50)8 (50)8 (21)8 (20)16 (50)
After subculture42
SA547 (VSSA)Initial0.52214
Final (passage no.)2 (50)8 (50)16 (36)8 (21)32 (48)
After subculture4432
SA262 (VSSA)Initial0.52114
Final (passage no.)4 (34)4 (50)4 (50)8 (16)>32 (22)
After subculture1432
SA248 (VSSA)Initial0.2510.50.54
Final (passage no.)2 (43)2 (50)4 (32)4 (41)16 (50)
After subculture210.5
SA618 (hVISA)Initial0.52424
Final (passage no.)2 (50)8 (50)16 (50)16 (14)16 (50)
After subculture8
SA873 (hVISA)Initial0.52212
Final (passage no.)2 (50)4 (50)16 (27)2 (50)8 (50)
After subculture4
SA555 (VISA)Initial1816162
Final (passage no.)2 (50)8 (50)32 (50)32 (50)4 (50)
After subculture
SA1287 (VISA)Initial0.54444
Final (passage no.)2 (50)8 (50)16 (50)8 (50)16 (50)
After subculture
SA1948 (VISA)Initial0.54244
Final (passage no.)2 (50)16 (50)32 (14)8 (50)8 (50)
After subculture16
SA770 (VISA)Initial0.54414
Final (passage no.)2 (50)8 (50)16 (50)8 (35)8 (50)
After subculture4
E. faecalis HMC568 (VSE)cInitial12122
Final (passage no.)1 (50)2 (50)2 (50)16 (21)32 (35)
After subculture1632
E. faecium HMC651 (VSE)Initial0.251142
Final (passage no.)1 (50)1 (50)2 (50)32 (24)2 (50)
After subculture16
  • a Time the MIC was measured.

  • b The MICs were determined by broth macrodilution. The MIC values in boldface type indicate that the clones were stable, which was defined as meaning that the MIC after the drug-free passages was within one dilution of the MIC before the drug-free passages. A minus sign means that no MIC increase greater than fourfold (as defined in Materials and Methods) occurred.

  • c VSE, vancomycin-susceptible enterococci.