TABLE 2.

Model building, parameters, and bootstrap runs for SDOX and NASDOX disposition

ParameterBase modelFinal covariate modelBootstrap replicates (n = 1,000; median [95% empirical CI])
OFV5,856.3045,826.3835,805.270 [5,467.562-6,105.249]
Pharmacokinetic parameters (estimate [RSE%])
    CL/FSDOX (liters/h/70 kg)0.0476 [6.1]0.0379 [7.4]0.038 [0.034-0.043]
    Pregnancy on CL/FSDOX (liters/h/70 kg)0.0181 [19.0]0.0179 [0.0122-0.024]
    VC/FSDOX (liters/70 kg)15.8 [2.7]15.8 [3.0]15.7 [14.9-16.7]
    VP/FSDOX (liters/70 kg)1.11 [22.9]1.11 [19.4]1.165 [0.715-1.74]
    ka (/h)0.769 [13.3]0.769 [15.3]0.763 [0.583-1.08]
    CLQ/F (liters/h/70 kg)0.0051 [47.8]0.0052 [44.5]0.0051 [0.00251-0.0125]
    CLM/F (liters/h/70 kg)0.0226 [5.0]0.0227 [5.0]0.023 [0.021-0.025]
    V/FNASDOX (liters/70 kg)3.68 [4.8]3.69 [5.3]3.72 [3.36-4.10]
Random parameters (CV% [RSE%])
    BSV CL/FSDOX36.3 [11.6]28.1 [10.1]27.1 [21.6-33.2]
    BSV VC/FSDOX19.8 [16.7]19.9 [9.1]19.6 [15.1-23.7]
    BSV ka99.3 [23]99.6 [15.2]97.1 [63.9-135]
    BSV CLM/F27.3 [12.2]27.3 [13.50]26.8 [20.6-33.2]
Residual unexplained variability (RUV)
    Proportional error in SDOX (CV% [RSE%])24.2 [5.7]24.1 [5.8]24.0 [21.4-26.7]
    Proportional error in NASDOX (CV% [RSE%])16.0 [7.8]16.0 [7.6]15.8 [11.5-18.3]
    Additive error in NASDOX (mg/liter [RSE%])0.202 [13.6]0.2 [13.5]0.202 [0.153-0.343]