TABLE 3.

Post hoc Bayesian predicted pharmacokinetic parameters for SDOX and NASDOX for PNG nonpregnant and pregnant women

ParameterMedian [IQR]Pa
Nonpregnant (n = 30)Pregnant (n = 30)
t1/2abs SDOX (h)0.93 [0.55-1.23]1.46 [0.65-2.15]0.064
CL/FSDOX (liters/h)0.030 [0.026-0.035]0.050 [0.043-0.053]<0.001
VC/FSDOX (liters)10.6 [9.9-11.9]12.3 [11.1-13.9]0.003
VP/FSDOX (liters)0.81 [0.75-0.88]0.86 [0.79-0.91]0.136
Vss/FSDOX (liters)11.5 [10.7-12.8]13.1 [11.9-15.0]0.002
t1/2α SDOX (h)110.8 [103.9-117.4]103.5 [93.3-108.7]0.013
t1/2β SDOX (h)200.5 [176.8-222.4]173.5 [162.3-182.6]<0.001
AUC0-∞ SDOX (mg·h/liters)33,284 [27,923-35,428]22,315 [19,844-24,967]<0.001
CLM/F (liters/h)0.017 [0.014-0.019]0.019 [0.017-0.023]0.011
CL/FNASDOX (liters/h)0.338 [0.295-0.397]0.567 [0.483-0.603]<0.001
V/FNASDOX (liters)3.1 [2.8-3.3]3.3 [3.0-3.4]0.136
t1/2 NASDOX (h)6.5 [5.0-7.7]4.1 [3.5-4.5]<0.001
AUC0-∞ NASDOX (mg·h/liters)1,590 [1,227-1,933]801 [610-989]<0.001
  • a As determined by the rank-sum test.