TABLE 5.

Post hoc Bayesian predicted pharmacokinetic parameters for PYR for PNG nonpregnant and pregnant women

ParameterMedian [IQR]Pa
Nonpregnant (n = 30)Pregnant (n = 30)
t1/2abs (h)0.41 [0.32-0.48]0.37 [0.29-0.47]0.234
CL/F (liters/h)0.707 [0.571-0.875]1.040 [0.901-1.383]<0.001
VC/F (liters)108.0 [96.6-117.8]174.2 [148.8-232.1]<0.001
VP/F (liters)67.4 [53.9-82.3]184.3 [154.7-222.6]<0.001
Vss/F (liters)175.9 [150.9-200.1]381.6 [301.5-434.9]<0.001
t1/2α (h)51.9 [43.7-56.6]75.1 [60.9-84.5]<0.001
t1/2β (h)237.3 [211.3-261.9]450.1 [349.1-500.3]<0.001
AUC0-∞ (μg·h/liters)106,065 [85,693-131,350]72,115 [54,250-83,229]<0.001
  • a As determined by the rank-sum test.